For citation purposes: Kokabu S, Sato T, Yoda T. TLE3 switch cell fate between osteoblast and adipocyte in bone marrow stromal cells. OA Biology 2014 Feb 22;2(1):3.

Review

 
Molecular

TLE3 switch cell fate between osteoblast and adipocyte in bone marrow stromal cells

S Kokabu, T Sato, T Yoda
 

Authors affiliations

Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Saitama Medical University, 38 Morohongo, Moroyama-machi, Saitama 350-0495, Japan

* Corresponding author Email: kokabu3@gmail.com

Abstract

Introduction

Osteoblasts and bone marrow adipocytes originate from bone marrow stromal cells. In senile osteoporosis, the balance between adipogenesis and osteoblastogenesis in bone marrow stromal cells is disrupted such that adipogenesis is increased with respect to osteoblastogenesis resulting in decrease in bone mass.

In general, there appears to be a reciprocal relationship between adipogenesis and osteoblastogenesis in bone marrow stromal cells. Although several proteins have been reported to regulate this process, the exact nature of the signals regulating the balance between osteoblast and adipocyte formation within the bone marrow space remains to be determined.

Recently, transducin-like enhancer of split 3 (TLE3) was reported to regulate the balance between osteoblast and adipocyte formation. TLE3 enhances adipocyte differentiation and suppresses osteoblast differentiation of bone marrow stromal cells in vitro. In addition, canonical Wnt signalling, which plays important role in both adipogenesis and osteoblastogenesis, induces TLE3 expression, suggesting that TLE3 activity may be key to balancing adipocyte and osteoblast differentiation within the adult bone marrow microenvironment. The aim of this review was to discuss TLE3 switch cell fate between osteoblast and adipocyte in bone marrow stromal cells.

Conclusion

Currently, there is demand for new effective therapies that target the stimulation of osteoblast differentiation to enhance bone formation. Reducing TLE3 expression in bone marrow stromal cells could be a useful approach towards increasing osteoblast numbers and reducing adipogenesis in the bone marrow environment. Thus, the development of a therapy that combines small interfering RNAs against TLE3 with a local delivery system targeting bone marrow stromal cells could lead to novel bone formation agonist.

Licensee OA Publishing London 2014. Creative Commons Attribution License (CC-BY)
Keywords