For citation purposes: Nazir U, Berger PA, Pitts LR, Satterwhite LG, Brownback KR. Role of thrombolytics in the management of sub-massive pulmonary embolism. OA Critical Care 2014 Feb 22;2(1):4.

Review

 
Critical Care Medicine & Pain

Role of thrombolytics in the management of sub-massive pulmonary embolism.

U Nazir, P Berger, L Pitts, L Satterwhite, K Brownback
 

Authors affiliations

(1) University of Kansas Medical Center, Kansas City, KS, U.S.A.

* Corresponding author Email: kbrownback@kumc.edu

Abstract

Introduction

Venous thromboembolism carries a high rate of in-hospital mortality, and pulmonary embolism is the third most common cause of cardiovascular death, with more than 600,000 cases occurring in the United States annually. The indications and use of thrombolytic therapy in the treatment of acute PE is highly controversial, especially regarding its use in the setting of sub-massive pulmonary embolism. This review discusses the risk stratification of patients with pulmonary embolism, outline prognostic factors, and discuss current recommendations and controversies regarding both systemic and catheter-directed thrombolytic use.

Conclusion

The use of thrombolysis, either catheter-directed or systemic, in sub-massive pulmonary embolism, remains controversial at this time.

Licensee OA Publishing London 2014. Creative Commons Attribution License (CC-BY)
Keywords