For citation purposes: Brezina PR, Kutteh WH, Bailey AP, Ding J, Ke RW. Preimplantation genetic screening: Pitfalls and opportunities. OA Genetics 2014 Feb 18;2(1):2.

Review

 
Developmental Genetics

Preimplantation genetic screening: Pitfalls and opportunities.

P Brezina,, W Kutteh,, A Bailey, J Ding, R Ke,
 

Authors affiliations

(1) Fertility Associates of Memphis, Memphis TN USA

(2) Vanderbilt University School of Medicine, Nashville TN USA

* Corresponding author Email: brezinamd@gmail.com

Abstract

Introduction

Preimplantation genetic screening is an increasingly utilized as a tool to optimize the efficiency of IVF in a variety of clinical situations. Initial data from PGS was discouraging using florescence in situ hybridization (FISH) and cleavage stage biopsy. However, more recently the trophectoderm biopsy at the blastocyst stage of embryonic development coupled with evaluation of all 23 chromosome pairs has yielded encouraging clinical results.

Conclusion


Current data suggests that appropriate application of PGS evaluating all 23 chromosome pairs with blastocyst stage biopsy may significantly improve the efficiency and efficacy of IVF for many patients.

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