For citation purposes: Van Dyke MW, Nelson LD. Triple helix-interacting proteins and cancer. OA Molecular Oncology 2013 Apr 01;1(1):5.

Critical review


Triple helix-interacting proteins and cancer

MW Van Dyke, LD Nelson

Authors affiliations

(1) Department of Chemistry and Biochemistry, Kennesaw State University, Kennesaw, Georgia, USA

(2) Department of Pediatrics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA

* Corresponding author Email:



Although most naturally occurring DNA and RNA adopt the now quite familiar double-helix structure, certain sequences can, under appropriate conditions, adopt a three-stranded, triple-helical structure. Both intramolecular and intermolecular triplexes have been described. Evidence for the existence of triplex structures in vivo is limited, although cellular proteins have been identified that avidly and specifically interact with such species. The postulated roles of triplexes and the proteins that interact with them in cancer and their potential utility as diagnostic markers are discussed in this article.


More studies will be needed before the full potential of triplex nucleic acids and their role in cancer can be realised.

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