(1) Department of Chemistry and Biochemistry, Kennesaw State University, Kennesaw, Georgia, USA
(2) Department of Pediatrics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
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Although most naturally occurring DNA and RNA adopt the now quite familiar double-helix structure, certain sequences can, under appropriate conditions, adopt a three-stranded, triple-helical structure. Both intramolecular and intermolecular triplexes have been described. Evidence for the existence of triplex structures
More studies will be needed before the full potential of triplex nucleic acids and their role in cancer can be realised.