Computational Biology & Biological Physics Laboratory, Lund University, Sölvegatan 14A, SE-223 62, Lund, Sweden
* Corresponding author Email: firstname.lastname@example.org
Embryonic stem cells exist in inter-convertible sub-states leading to observed heterogeneity arising from seemingly homogeneous populations. Recently, it has been proposed that the stem cell compartment contains the ground state characterised by naïve pluripotency. Understanding molecular dynamics governing the transition from and towards naïve stem cell state is crucial for stem cell biology. It is important to elucidate molecular interactions that regulate lineage commitment and the reprogramming of somatic cells into naïve pluripotent cells. We review key experimental and computational studies that provide an improved understanding and characterisation of the molecular aspects underlying stem cell naïve pluripotency and their impact in the context of reprogramming.
Further computational efforts should be made for elucidating the molecular interaction dynamics governing the transitions between naïve and primed hES cells states.