For citation purposes: Pan Y. Role of Stat3 in nasopharyngeal carcinoma. OA Cancer 2013 Dec 30;1(2):17.

Review

 
Basic Cancer Biology

Role of Stat3 in nasopharyngeal carcinoma

Y Pan,
 

Authors affiliations

(1) Department of Pathophysiology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong 510080, P.R. China

(2) Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China

* Corresponding author Email: panyunbao@outlook.com

Abstract

Introduction

Nasopharyngeal carcinoma is an Epstein–Barr virus-associated head and neck cancer which is most common in eastern Asia. Epstein–Barr virus infection, environmental factors and genetic susceptibility play important roles in nasopharyngeal carcinoma pathogenesis. Correlation of signal transducer and activator of transcription-3 (Stat3) overexpression with poor prognosis for nasopharyngeal carcinoma provides evidence that it is involved in the tumourigenic process. In this review, we highlight recent advances in studies on the oncogenic role of Stat3 in nasopharyngeal carcinoma and its potential as a therapeutic target for this cancer.

Conclusion

Despite different approaches to identify small molecules that effectively inhibit Stat3 signalling, further studies will be needed to make these molecules more effective for improved clinical outcomes.

Licensee OA Publishing London 2013. Creative Commons Attribution License (CC-BY)
Keywords