For citation purposes: da Cunha MG, Macedo MS, Fonseca FLA, Filho CDASM. The importance of the evaluation of androgen levels in adult women with acne: Brazilian casuistic report. OA Dermatology 2013 Dec 30;1(1):7.

Research study

 
Laboratory & Clinical Investigations

The importance of the evaluation of androgen levels in adult women with acne: Brazilian casuistic report.

M da Cunha, M Macedo, F Fonseca, CDASM Filho
 

Authors affiliations

(1) Dermatologist; in charge of the Acne-in-Adult-Women Ambulatory Clinic in the discipline of dermatology and the postgraduate cosmiatry course at Faculdade de Medicina do ABC (FMABC), Brazil

(2) Universidade Federal de São Paulo (UNIFESP); assistant in the Acne-in-Adult-Women Ambulatory Clinic in the discipline of dermatology at FMABC, Brazil

(3) Federal University of São Paulo, Diadema, Brazil

(4) Full Professor in the discipline of dermatology at FMABC, Brazil

* Corresponding author Email: profferfonseca@gmail.com

Abstract

Introduction

Acne in adult women is a hard-to-manage frequent disease with many relapse cases. It mostly interferes with the quality of life and causes major social and metabolic losses for patients. This is a transversal retrospective study whose aim is to identify the androgen profile in patients who were treated at the Acne-in-Adult-Women Ambulatory Clinic in the Dermatology Department of Faculdade de Medicina do ABC (FMABC) from 2008 to 2012, and who presented altered frequency and profile of the hormones.

Materials and methods

In this study, we reviewed 201 medical records of women above 15 years of age, with the onset or worsening of acne cases, treated at the ambulatory clinic. The levels of the hormones DHEA-S, DHEA, DHT, androstenedione and total and free testosterone were measured in all patients.

Results

The evaluation of the hormonal profile showed that 60% of the patients had hyperandrogenemia, and the levels of DHEA were the most frequently elevated.

Conclusion

Therefore, in the face of the importance of the hyperandrogenemia in the pathogenesis of acne, the standardization of circulating androgen levels and the early detection of hyperandrogenic states prove to be useful for a more precise evaluation of each patient and for the choice of the best therapeutic conduct. To establish a model for the research of hormonal profile is paramount for relapse control in the event of a surge of acne breakouts in a woman’s adult life.

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