Department of Surgical Oncology, Oncology Institute of Geriatrics and Medical Science, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka City, Osaka 545-8585, Japan
* Corresponding author Email: email@example.com
Scirrhous gastric cancer, diffusely infiltrating carcinoma, or Borrmann type 4, also known as linitis plastica-type carcinoma, is characterised by rapid cancer cell proliferation and infiltration accompanied by extensive stromal fibrosis. Scirrhous gastric cancer cells easily invade and diffusely spread into the gastric wall. The common features of scirrhous gastric cancer include rapidly progressive invasion and a high frequency of metastasis to the peritoneum. Scirrhous gastric cancer accounts for approximately 10% of all gastric cancers and its prognosis is worse than that of other types of gastric cancer due to its aggressive behaviour and the lack of effective therapies. The aim of this critical review is to discuss scirrhous gastric cancer.
Despite an increase in the understanding of the molecular pathways involved in scirrhous gastric cancer, clinical studies have not identified agents that are effective in the treatment of this disease. The recent understanding of the molecular biology underlying the characteristics of scirrhous gastric cancer might provide a deeper diagnosis and development of treatment strategies for scirrhous gastric cancer.