For citation purposes: Kolar GR, Elrick MM, Yosten GLC. G protein-coupled receptor signaling: Implications for the treatment of diabetes and its complications. OA Evidence-Based Medicine 2014 Jan 18;2(1):2.

Review

 
Treatment

G protein-coupled receptor signaling: Implications for the treatment of diabetes and its complications.

G Kolar, M Elrick, G Yosten
 

Authors affiliations

(1) Saint Louis University School of Medicine, Saint Louis, Missouri, USA

* Corresponding author Email: gyosten@slu.edu

Abstract

Introduction

G protein coupled receptors (GPCRs) represent the most abundant receptor family encoded by the human genome, and are the targets of a large percentage of drugs currently prescribed in the United States. Recently, several GPCRs have been identified as potential therapeutic targets for the treatment of diabetes and diabetes-associated complications, including retinopathy, nephropathy, and neuropathy.

Conclusion

In this review, we will discuss GPCR structure and signalling cascades, as well as highlight GPCR-based therapeutics that are currently prescribed or are in clinical trials to combat diabetes and its complications, a disease which now affects over 347 million patients worldwide.

Licensee OA Publishing London 2014. Creative Commons Attribution License (CC-BY)
Keywords