(1) University of Ferrara, Ferrara, ITALY
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The treatment of facial aging features has led to the development of several skin fillers over the past few years. Today, dermal fillers are commonly subdivided on the basis of by their turnover in the skin in temporary, semi-permanent, and permanent.
Permanent fillers may be identified by their morphological aspects. There are a number of permanent fillers each of them with its own strengths, drawbacks, and indications. Patients and clinicians desire both a safe product and a durable correction. However, an inflammatory and fibrotic reaction is developed at their contact, depending on the nature of the product and the patient.
This review relates to the morphological aspect of permanent fillers (Polymethylmethacrylate, Polymethylmethacrylate plus hyaluronic acid, Polydimethyl-siloxane, Polyacrylamide Gel, Alkylamides, and Silicone), the normal tissue reaction after injection, and more frequently observed side effects.
They mainly complications following permanent fillers use consist of granulomatous reactions with inflammatory nodules which may appear long after injection. So, the suggestion is to use a temporary injectable product to minimize the inconvenience and cost of permanent fillers injections.