Head and Neck Oncology

Case series

Translational Innovations & Methodology

Mondrik SM, Schwarz RA, Pierce MC, King TJ, Bhattar V , Howe JM , Dhar S, Williams MD, Vigneswaran N , Gillenwater AM, Richards-Kortum R. Surveillance of patients with oral potentially malignant disorders using optical imaging: A case series. Head Neck Oncol 2014 Aug 18;6(4):37.


Introduction: Surveillance of patients with oral potentially malignant disorders (OPMD) such as leukoplakia and oral lichen planus can be challenging, even for experienced clinicians. New optical technologies are being developed to assist clinicians in detecting and recognizing early cancers and high grade dysplasia.

Methods and Results: To assess the feasibility of optical imaging to assist in the follow-up surveillance of patients at high risk for development of oral cancer, we examined patients with autofluorescence imaging at successive clinic visits. We present three representative cases and compare features of optical imaging over time to the surrogate endpoints of clinical appearance and the histopathologic grade of dysplasia during the follow-up period.

Conclusion: These three cases illustrate how autofluorescence imaging can be used over time to gather additional clinical data with potential diagnostic relevance. Specifically, we observed optical changes in OPMD lesions prior to discernable clinical changes prompting the clinician to biopsy.

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