For citation purposes: Cerrato E, Calcagno A, D?Ascenzo F, Biondi-Zoccai G, Quadri G, Omede P, Abbate A, Bonora S, Moretti C, Gaita F. Acute coronary syndrome in human immunodeficiency virus patients: exploiting physiopathology to inform the clinical practice. OA Evidence-Based Medicine 2013 May 01;1(1):5.

Review

 
Treatment

Acute coronary syndrome in human immunodeficiency virus patients: exploiting physiopathology to inform the clinical practice

E Cerrato, A Calcagno, F D’Ascenzo, G Biondi-Zoccai, G Quadri, P Omede, A Abbate, S Bonora, C Moretti, F Gaita
 

Authors affiliations

(1) Division of Cardiology, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy

(2) Division of Infectious Disease, Amedeo di Savoia Hospital, Turin, Italy

(3) Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy

(4) VCU Pauley Heart Center, Richmond, VA, USA

*Corresponding author E-mail: enrico.cerrato@gmail.com

Abstract

Introduction

Nowadays in developed countries, human immunodeficiency virus-infected subjects could access a highly active anti-retroviral therapy. In this setting, greater attention has been paid to the impact of premature atherosclerotic cardiovascular disease that, actually, represents a leading cause of morbidity and mortality. Higher rates of traditional risk factors along with human immunodeficiency virus infection and adverse effects of anti-retroviral agents represent important proatherogenic factors. Physicians treating human immunodeficiency virus-positive patients should consequently aim at intensively modifying risk factors, controlling drug-to-drug interactions and selecting anti-retroviral drugs with a lower cardio-metabolic impact. The aim of this study was to discuss acute coronary syndrome in human immunodeficiency virus patients.

Conclusion

Short-term benefits of specific anti-retrovirals prevent cardiovascular disease in human immunodeficiency virus patients, but long-term benefits need more data and longer-term follow ups to be correctly assessed.

Licensee OA Publishing London 2013. Creative Commons Attribution License (CC-BY)
Keywords