Medical Microbiology and Immunology, Genome Center, MIND Institute, University of California, Davis, CA, USA
*Corresponding author Email: email@example.com
Autism-spectrum disorders are complex genetic disorders collectively characterised by impaired social interactions and language as well as repetitive and restrictive behaviours. Of the hundreds of genes implicated in autism-spectrum disorders, those encoding proteins acting at neuronal synapses have been most characterised by candidate gene studies. However, recent unbiased genome-wide analyses have turned up a multitude of novel candidate genes encoding nuclear factors implicated in chromatin remodelling, histone demethylation, histone variants and the recognition of DNA methylation. Furthermore, the chromatin landscape of the human genome has been shown to influence the location of
Considering the many roles that chromatin plays at the interface of genetic and environmental factors in regulating gene expression and epigenetic states, it is perhaps not surprising that genomic approaches keep uncovering chromatin-encoding genes.