For citation purposes: Sharawy N. Prediction of acute Kidney injury during sepsis: Unsolved mystery yet. OA Critical Care 2013 Oct 01;1(2):14.

Critical Review

Anaesthesiology, Perioperative & Critical Care Medicine

Prediction of acute kidney injury during sepsis: unsolved mystery yet

N Sharawy,

Authors affiliations

(1) Department of Anaesthesia, Dalhousie University, Sir Charles Tupper Medical building, Room 6H-1, 5850 College street, Halifax, Nova Scotia B3H 2Y9, Canada

(2) Kasr EL Eni, Faculty of Medicine, Cairo University, Cairo, Egypt

*Corresponding author Email:



Acute kidney injury (AKI), the most common part of the multiple organ dysfunction syndrome, is the most frequent cause of death in septic patients admitted to intensive care units. The pathogenesis of sepsis-induced AKI is a controversy area. Whether pre-renal transit AKI or direct tubular injury is the determinant factor for development of permanent renal AKI during sepsis, remain a matter of debt. In addition, the renal hemodynamic changes during sepsis is another unanswered question.


Full understanding of the mechanism of AKI is an essential step for development of ideal biomarker or tool, which is one of the research priority today The aim of this review are to discuss briefly the recent suggested mechanisms of AKI, and to outline the current development in AKI predictive tool and marker during septic shock.

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