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Does Cannabinoid Inhibit COVID-19 Infection?

The fast spread of COVID-19 emphasises the need for novel therapies. Cannabidiol (CBD), a component of the cannabis plant, protects against SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, were reported to decrease SARS-CoV-2 replication in lung epithelial cells effectively. Even though specific cannabis compounds may prevent the COVID-19 virus from entering human cells, marijuana use does not give protection. Cannabidiolic acid (CBGA) and cannabidiolic acid (CBDA) are two hemp compounds that help to keep SARS-CoV-2, a potentially fatal virus, at bay. "These cannabinoid acids are numerous in hemp and varied hemp extracts," says Richard van Breemen of Oregon State University's Global Hemp Innovation Center in the College of Pharmacy and the Linus Pauling Institute. Unlike THC, the pleasurable element in marijuana, these chemicals are unregulated and have a good safety profile in humans. The researchers discovered that hemp compounds were equally effective against SARS-CoV-2 variants B.1.1.7, discovered in the United Kingdom, and B.1.351, discovered in South Africa. "Our study also discovered that hemp compounds were effective against SARS-CoV-2 variants, including variant B.1.1.7, which was discovered in the UK "Breemen". " According to the researchers, the study's results were published on Monday in the Journal of Natural Products.

CBD And COVID-19 Vaccine

CBD usage and Covid-19 vaccination are rising. So, what's next? CBD's anti-inflammatory properties may help some people. Several scientists say vaccine candidates should avoid CBD. It doesn't mean the covid-19 vaccine and CBD have a bad interaction. CBD probably won't affect immunizations. Precautions should be taken. CBD changes inflammatory and immunological responses. Thus it should be avoided. Discontinue CBD usage a week before and a few weeks after immunization. A little CBD here, and it isn't dangerous. Only for high-CBD users! Prescribing low-dose CBD may not need to learn about the risks of CBD combining with cancer drugs. It's a mystery. Experts advise against overdosing on CBD to treat Covid-19. Vaccines and CBD supplements do not interact clinically. CBD is thus safe to use alongside vaccines. Due to a lack of proof, several experts advise stopping CBD consumption before vaccination. Contrast CBD supplements with recreational or medical marijuana use. Some people who smoke marijuana regularly may have a bad reaction to the vaccine. Conversely, CBD supplements are safe and have no clinically significant impact on immune responses. This is useful for pre-and post-vaginal exams.

CBD Dosage For COVID

According to Heute, on January 31, 2021, an Austrian hospital started using CBD to treat COVID-19 patients. During the three-week treatment phase, Klagenfurt doctors increased the CBD dosage for COVID-19 to 300mg. "We discovered that people left the hospital sooner and had reduced levels of inflammation in their blood." According to Rudolf Likar, Intensive Care Head at Klagenfurt Clinic, CBD benefits the immune system. CBD is anticipated to grow more popular in this location. According to reports, CBD is approved for COVID-19 therapy in Tel Aviv. In April of this year, Israeli researchers launched several CBD research projects in COVID-19 patients. CBD will most likely be used at more hospitals to treat COVID-19 patients. CBD has been shown to reduce cytokine storm, the leading cause of mortality in COVID-19 patients. A cytokine storm is an organic reaction that produces pulmonary inflammation, blood vessel blockage, and organ failure. The terrifying aspect of this reaction is that it develops quickly, within 24 to 48 hours, leaving clinicians powerless to save the patient's life. Because the cytokine storm causes ARDS, patients need a respirator. According to statistics, 30-50 percent of those who use a respirator will die.

Congeneric Cannabinoids

A New Perspective on the claimed introductory medical chemistry of cannabidiol (CBD) provides evidence that the widespread usage of CBD-fortified or CBD-labeled health products, as well as the marketing of CBD-associated health claims, has a solid scientific foundation. One famous critique of CBD is that it is being marketed as a panacea, putting it in the same category as other "natural" medicines. True ethnobotanicals are reduced to a few active compounds that are helpful. Using reductionist techniques to solve problems oversimplifies valuable, chemically complicated combinations, all while attempting to justify and capitalize on the economic value of natural substances by claiming that they are "natural." According to published literature, CBD has been linked to some semiubiquitous, extensively screened compounds, mainly derived from plants, that interfere with bioassays and have a low potential for becoming therapeutic agents. Increased health concerns and pandemic crises like SARS-CoV-2 create conditions in which scientists must be especially cautious about therapeutic claims that are not supported by solid empirical evidence.

Conclusion

COVID-19 is a game-changer on a worldwide scale: everyday routines and work habits have been entirely flipped upside down. Consumers' physical and emotional well-being have been harmed by the constant tension and immobility, which is infused with a feeling of uncertainty. However, this presents a chance for cannabinoids like CBD to enhance consumer health in the post-COVID context, showcasing the potency of this strong plant once again.

Finally, it is critical to distinguish between CBD supplements and recreational cannabis/marijuana usage or medicinal marijuana use. Those who use heavy doses of medicinal marijuana or who use marijuana often for recreational reasons may have a muted reaction to the vaccination in certain situations. CBD has a demonstrated safety record and does not seem to have a clinically significant effect on immunological responses.

About The Authors

Suleman Shah

Suleman Shah - Suleman Shah is a researcher and freelance writer. As a researcher, he has worked with MNS University of Agriculture, Multan (Pakistan) and Texas A & M University (USA). He regularly writes science articles and blogs for science news website immersse.com and open access publishers OA Publishing London and Scientific Times. He loves to keep himself updated on scientific developments and convert these developments into everyday language to update the readers about the developments in the scientific era. His primary research focus is Plant sciences, and he contributed to this field by publishing his research in scientific journals and presenting his work at many Conferences. Shah graduated from the University of Agriculture Faisalabad (Pakistan) and started his professional carrier with Jaffer Agro Services and later with the Agriculture Department of the Government of Pakistan. His research interest compelled and attracted him to proceed with his carrier in Plant sciences research. So, he started his Ph.D. in Soil Science at MNS University of Agriculture Multan (Pakistan). Later, he started working as a visiting scholar with Texas A&M University (USA). Shah’s experience with big Open Excess publishers like Springers, Frontiers, MDPI, etc., testified to his belief in Open Access as a barrier-removing mechanism between researchers and the readers of their research. Shah believes that Open Access is revolutionizing the publication process and benefitting research in all fields.

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