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Effects Of CBD In The Brain And Body

CBD has an effect on our bodies by indirectly stimulating the CB1 and CB2 receptors while also inhibiting the breakdown of our own endogenous cannabinoid anandamide, effectively making CBD a reuptake and breakdown inhibitor. CBD in the brain and body raises anandamide levels, which may explain why CBD has been shown to be useful in the treatment of seizures. CBD has anti-anxiety and anti-inflammatory properties because it acts as a reuptake inhibitor (preventing reabsorption) for the neurotransmitter adenosine. CBD also has a therapeutic impact via binding to a number of non-cannabinoid receptors in the brain.

CBD affects anxiety, appetite, sleep, pain perception, mood, nausea and vomiting, and sexual behavior, to mention a few, by directly activating the serotonin 5HT1A receptor. CBDA (the acidic version of CBD found in raw plants; see page 45 for more details) has a high affinity for the 5-HT1A serotonin receptor, and is proven to have even stronger anti-nausea effects than CBD and THC, according to new research. CBD also has a direct interaction with the TRPV1 receptor, which is involved in pain perception, inflammation, and body temperature regulation. The TRPV1 receptor is also stimulated by our own endogenous anandamide.

CBD inhibits the GPR55 receptor, which may assist to prevent osteoporosis and cancer cell proliferation. CBD can also have an antiproliferative impact and restrict tumor growth in human lung cancer through activating the PPAR-gamma receptor. PPAR-gamma activation may also aid in the degradation of amyloid-beta plaques linked to Alzheimer's disease. PPAR receptors also regulate genes involved in energy balance, lipid absorption, insulin sensitivity, and other metabolic activities, as if that wasn't enough. CBD may be a potential therapy option for diabetes and other metabolic disorders due to its effect on PPAR receptors.

CBD provides an astonishing array of therapeutic effects, benefits that go far beyond symptom relief to provide deep repair at the molecular level, thanks to its activity on all of these receptors. Take a look at the list of CBD's most important therapeutic characteristics! Research in all of these areas will continue to improve our understanding of CBD and the ECS in general, as well as find new and fascinating CBD uses.

A closed black tincture bottle with a black cover beside three cannabis leaves
A closed black tincture bottle with a black cover beside three cannabis leaves

Let's look at one more key way that CBD, and other cannabinoids, benefit our health. Phytocannabinoids have antioxidant and neuroprotective capabilities, and they're powerful ones.

You may be aware of the need of antioxidants, but you may not realize how critical they are. Antioxidants are produced by our bodies, but not nearly enough to offset the amount of oxidative stress that we are exposed to in modern life. Antioxidant-rich diets have been demonstrated to lower the risk of diseases like cardiovascular disease, stroke, Parkinson's, Alzheimer's, and arthritis. Antioxidants offer therapeutic potential in avoiding the forms of free radical damage linked to cancer, according to the National Cancer Institute. One of the first studies to document CBD's antioxidant effects was published in 1998, and CBD was discovered to be a more effective antioxidant than both vitamins C and E.

Neuroprotectants, unsurprisingly, protect our brains. CBD acts as a neuroprotectant, reducing brain and nervous system damage while also encouraging the growth and production of new neurons. Ischemia (inadequate blood supply), traumatic blows, or autoimmune and genetic illnesses can induce oxidative stress, which can cause temporary or permanent neurological damage. However, studies have shown that CBD can protect against this damage and promote recovery.

CBD may be useful in the treatment of traumatic brain injuries, spinal cord injuries, spinal cord disorders, and strokes, according to these data. CBD's neuroprotective effects may also be useful in preventing and slowing the progression of neurological diseases like ALS, epilepsy, MS, and Parkinson's disease. More research is needed to determine the effectiveness of CBD in enhancing cell and neuron health, but the evidence so far shows that CBD could be utilized to reduce neural and cell damage and promote repair.

CBD Doesn’t Get You High

One of the most widely stated advantages of CBD is that it does not make you high. This point is extremely essential to many people, and it makes CBD an appealing therapy choice for those who cannot take THC.

Because of the lack of euphoria, many people mistakenly believe CBD is non-psychoactive, which it isn't. So, while CBD won't make you high, it's not fully correct to state that it's not "psychoactive." These phrases (non-psychotropic/non-psychoactive) are misleading, according to Dr. Ethan Russo, "considering its (CBD's) notable pharmacological advantages on anxiety, schizophrenia, addiction, and potentially even depression."

Cannabidiol has an obvious mental influence; it's one of its most appreciated effects. Just because something has an effect on your brain doesn't mean it's a bad thing. And just because you're acting on your mind doesn't imply you'll get high. Many medications (such as antidepressants) act on the mind and do not cause you to get high!

Of course, CBD's non-intoxicating properties are extremely beneficial, and the fact that it does not get you high makes it more versatile than high-THC treatment options. We're here to dispel the myths around THC's euphoric effects, because THC can not only make you feel good, but it can also have medicinal benefits.

THC and CBD also have a unique symbiotic interaction. They both have anti-inflammatory and analgesic properties, but they do so via different processes in the body and brain. As a result, the total effect will be more robust. CBD also delays the body's breakdown of THC, prolonging its medicinal effects.

Five balls of cannabis leaves beside a rolled blunt of cannabis
Five balls of cannabis leaves beside a rolled blunt of cannabis

Is Getting High Bad?

The assumption that taking medication to feel better isn't proper or acceptable seems to apply to cannabis almost exclusively. Antidepressants and tranquilizers, for example, are designed to make us feel better emotionally. Of course, for some people, the euphoria associated with THC may be completely off-limits and unwanted, and it may not be effective or acceptable in some settings. However, the impacts of laughing, enjoying food, music, and the company of others more, feeling a spark of creativity, and being more open-minded and patient can be just as therapeutic as pain relief and inflammation reduction. Steve DeAngelo, a well-known cannabis activist and advocate, calls them the "forgotten wellness benefits" of cannabis.

The Bottom Line

Cannabis plants contain a variety of cannabinoids, including CBD. The chemical may be beneficial for a variety of conditions, including stress, anxiety, depression, epilepsy, pain, and inflammation.

While pure CBD is generally deemed harmless, the federal government in the United States does not control all parts of it. The government, for example, does not confirm or approve the purity of substances supplied by producers. When it comes to claims about health benefits, the CBD business has far overtaken scientific study.

The first step toward responsible CBD use is to understand what CBD does in the body. While there are still some unknowns, the chemical appears to be a potential therapy option.

About The Authors

Suleman Shah

Suleman Shah - Suleman Shah is a researcher and freelance writer. As a researcher, he has worked with MNS University of Agriculture, Multan (Pakistan) and Texas A & M University (USA). He regularly writes science articles and blogs for science news website immersse.com and open access publishers OA Publishing London and Scientific Times. He loves to keep himself updated on scientific developments and convert these developments into everyday language to update the readers about the developments in the scientific era. His primary research focus is Plant sciences, and he contributed to this field by publishing his research in scientific journals and presenting his work at many Conferences. Shah graduated from the University of Agriculture Faisalabad (Pakistan) and started his professional carrier with Jaffer Agro Services and later with the Agriculture Department of the Government of Pakistan. His research interest compelled and attracted him to proceed with his carrier in Plant sciences research. So, he started his Ph.D. in Soil Science at MNS University of Agriculture Multan (Pakistan). Later, he started working as a visiting scholar with Texas A&M University (USA). Shah’s experience with big Open Excess publishers like Springers, Frontiers, MDPI, etc., testified to his belief in Open Access as a barrier-removing mechanism between researchers and the readers of their research. Shah believes that Open Access is revolutionizing the publication process and benefitting research in all fields.

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