• Medicine
  • Spirituality
  • Astronomy
  • Sociology
  • Technology
  • History
  • Open Access
  • News

Mucinus Producing Hepatic Cystic Lesions Radiology – What Are They? Diagnosis And Treatment

Mucinus producing hepatic cystic lesions radiology demonstrates it is critical to distinguish mucinous cystic neoplasm of the liver from the intraductal papillary tumor of the bile duct from more frequent cystic hepatic masses because they have different malignant potential, therapy, and prognosis.

Mucinous cystic neoplasm of the liver (MCN) and intraductal papillary neoplasm of the bile duct (IPNB) are uncommon and different entities with discrete clinical, pathologic, and imaging characteristics. The presence of subepithelial ovarian-like hypercellular stroma (OLS), the distinguishing histopathologic hallmark of MCN, distinguishes them pathologically.

MCN is a benign, giant, solitary, symptomatic, multiloculated cystic tumor that often arises in middle-aged women. On the other hand, NBC is a diverse spectrum of tumors that are usually linked with invasive carcinoma, occurs in older individuals, and may be distinguished from MCN by contact with the biliary tree, intraductal masses, concomitant biliary ductal dilatation, and the absence of OLS.

Understanding these rare neoplasms has grown and evolved and continues to do so today. Still, uncertainty and controversy persist due to the tumors' rarity, relatively recent designation as separate entities, inherent clinicopathologic heterogeneity, overlapping imaging features, and the fact that many prior studies likely included MCN and cystic IPNB as a single entity.

Historical discrepancies and nonstandardized terminology have contributed to confusion about these neoplasms. The interpreting radiologist must know these entities to suggest a specific diagnosis or generate a meaningful differential diagnosis in the appropriate setting.

This is especially important because MCN and cystic IPNB have overlapping imaging features with other more common hepatobiliary cystic masses but have different management and prognosis.

Liver in a woman's body
Liver in a woman's body

Biliary Cystadenoma

Biliary cystadenomas are rare benign cystic liver neoplasms. Biliary cystadenomas mainly affect middle-aged individuals and are more frequent in women. The clinical appearance of biliary cystadenomas varies according to tumor size and location. Symptoms and warning signals may include:

  • Obstructive jaundice
  • Palpable liver edge
  • Mass rising abdominal girth
  • Right upper quadrant discomfort (large tumors)
  • Vomiting and nausea

Biliary cystadenomas are cystic neoplasms that may be unilocular or multilocular. They are only sometimes detected in the extrahepatic biliary tree and gallbladder. Cysts bordered with cuboidal or columnar epithelium mimic normal biliary epithelium. Generally, the criteria for cystadenomas are not connected with the bile ducts, and a variable quantity of mucin-producing epithelium is linked with ovarian-type subepithelial stroma.

Biliary cystadenomas may be unilocular or multilocular and vary in size from 3 to 40 cm. Unfortunately, no imaging findings may reliably distinguish biliary cystadenoma from biliary cystadenocarcinoma.

A biliary cystadenoma manifests as a unilocular or multilocular cyst with the increased transmission. The cysts might be entirely anechoic or have low-level echoes from blood products, mucus, or proteinaceous fluid. Mural nodules and papillary projections may also protrude into the cyst lumen. Acoustic shadowing may be seen if septal or wall calcification is present.

Although biliary cystadenomas are benign tumors, they may return after excision and can progress to malignant biliary cystadenocarcinomas.

Mucinous Cystic Neoplasm Of The Liver

Mucinous cystic neoplasms of the liver (MCN-L), also known as cystadenomas or cystadenocarcinomas, are uncommon cystic tumors that develop in the liver parenchyma or, less commonly, in the extrahepatic bile ducts. They are estimated to account for 5% of all liver cysts. MCN-L is distinguished from an intraductal papillary neoplasm of the bile duct (IPNB), intrahepatic cholangiocarcinoma with cystic change, echinococcal cyst, and simple cyst. Microscopic examination for ovarian-type stroma is the only way to distinguish invasive MCNs from non-invasive MCNs. To distinguish MCNs from other cystic liver lesions, an intraoperative sample and frozen section(s) are required. With a proper early diagnosis, the treatment of choice is complete excision, which may result in excellent survival. However, its uncommon occurrence and limited detection usually result in an inaccurate first or delayed diagnosis or misdiagnosis.

Hepatic Mucinous Cystic Neoplasm Versus Simple Biliary Cyst

Hepatic cystic lesions are a frequent condition that affects up to 20% of the general population. Mucinous cystic neoplasm of the liver, also known as "biliary cystadenoma," is an uncommon cystic lesion with a 20% chance of malignant progression to mucinous cystic neoplasms with invasive characteristics. Because of the rarity of the lesion, research on hepatic mucinous cystic neoplasms has been limited. Because of the differences in care, presurgical identification of a hepatic mucinous cystic neoplasm from a typical biliary cyst is critical.

MCN recurs in up to 45.6 percent of cases when treated with unroofing and fenestration rather than excision. Other studies have evaluated cyst fluid analysis performance, such as carbohydrate antigen and carcinoembryonic antigen levels.

People Also Ask

Is Biliary Cystadenoma Cancerous?

Mucinous cystic neoplasms (MCNs) are cysts that are not generally malignant but may develop into malignancy. MCNs are often located in the pancreas's body or tail.

What Is Mucinous Cystic Neoplasm With Low Grade Dysplasia?

Mucinous cystic neoplasm (MCN) is an uncommon exocrine pancreatic tumor with four histological forms: noninvasive MCN with low-grade, intermediate-grade, or high-grade dysplasia, and invasive MCN.

What Is A Mucinous Cyst?

Mucinous cystic neoplasms (MCN) are large unilocular or multilocular thick-walled cysts that are often filled with mucinous fluid but may also include hemorrhagic or serous fluid. The cysts in high-grade MCN may have solid patches, mural nodules, or papillary projections.

Are Mucinous Cysts Cancerous?

Biliary cystadenomas develop from the biliary epithelium and often contain a brown or greenish fluid that resembles bile. Because they have the potential to become cancerous, the objective of surgery should be full excision through formal hepatic resection or enucleation.


Mucinous cystic neoplasms of the liver are uncommon cystic tumors that develop inside the liver parenchyma and account for 5% of all liver cysts. Because of its rarity and lack of identification, it usually results in delayed or misdiagnosed diagnoses. Mucinous cystic neoplasms should always be included in the preoperative differential workup of a cystic liver tumor. When the patient is physically suitable for surgery and there is no sign of systemic illness on the first workup, complete excision of a suspected non-invasive or invasive Mucinous cystic neoplasms of the liver is the therapy of choice. As mucinous cystic neoplasms are resected more often, and the proper categorization is used, survival rates and prognosis will become more defined.

About The Authors

Suleman Shah

Suleman Shah - Suleman Shah is a researcher and freelance writer. As a researcher, he has worked with MNS University of Agriculture, Multan (Pakistan) and Texas A & M University (USA). He regularly writes science articles and blogs for science news website immersse.com and open access publishers OA Publishing London and Scientific Times. He loves to keep himself updated on scientific developments and convert these developments into everyday language to update the readers about the developments in the scientific era. His primary research focus is Plant sciences, and he contributed to this field by publishing his research in scientific journals and presenting his work at many Conferences. Shah graduated from the University of Agriculture Faisalabad (Pakistan) and started his professional carrier with Jaffer Agro Services and later with the Agriculture Department of the Government of Pakistan. His research interest compelled and attracted him to proceed with his carrier in Plant sciences research. So, he started his Ph.D. in Soil Science at MNS University of Agriculture Multan (Pakistan). Later, he started working as a visiting scholar with Texas A&M University (USA). Shah’s experience with big Open Excess publishers like Springers, Frontiers, MDPI, etc., testified to his belief in Open Access as a barrier-removing mechanism between researchers and the readers of their research. Shah believes that Open Access is revolutionizing the publication process and benefitting research in all fields.

Recent Articles

  • Generative Model - How Is It Used In Studying Brain Dynamics?

    Generative Model - How Is It Used In Studying Brain Dynamics?

    A generative model might be a set of equations that define the development of human patient signals depending on system factors.

  • Life Path 9 And 6 Compatibility - Extremely Compatible

    Life Path 9 And 6 Compatibility - Extremely Compatible

    In this post, we'll discuss the life path 9 and 6 compatibility and show you how to use numerology to identify your soul mate. Be aware that numerology may be used to determine relationship compatibility.

  • Life Path Number 7 And 9 Compatibility - Harmony, Peace, And Prosperity In Life

    Life Path Number 7 And 9 Compatibility - Harmony, Peace, And Prosperity In Life

    According to life path number 7 and 9 compatibility, this combination belongs to the category of neutral combinations.

  • Dream About A Flat Tire - Reflect One's Insecurity

    Dream About A Flat Tire - Reflect One's Insecurity

    A dream about a flat tire means a variety of things. These dreams typically involve your feelings and ideas about the future, whether it's about your future in general or a specific future event or circumstance. Given the conditions, it may be extremely easy to dream of flat tires.

  • 456 Angel Number Twin Flame Symbolizes Existence

    456 Angel Number Twin Flame Symbolizes Existence

    When it comes to the 456 angel number twin flame, You now have the opportunity to locate your twin flame and bring your need for a relationship with them to fruition.

  • Men May Have A Greater Cancer Rate Due To Biological Differences

    Men May Have A Greater Cancer Rate Due To Biological Differences

    For many years, lifestyle elements including smoking, drinking, and eating habits were blamed for this gap. But more recent studies imply that there are also other elements at work.

  • Our OAPL Specialist - PHD, MBA, Suleman Shah

    Our OAPL Specialist - PHD, MBA, Suleman Shah

    Suleman Shah is a freelance writer and researcher. He has collaborated with MNS University of Agriculture in Multan, Pakistan, and Texas A&M University (USA). His principal research interest is plant sciences, and he has contributed to this area by publishing his findings in peer-reviewed publications and presenting his findings at several conferences.

  • Dreaming Of Being Shot - Scared, Angry And Confused

    Dreaming Of Being Shot - Scared, Angry And Confused

    Having recurring nightmares in which you are shot might leave you feeling frightened, enraged, and bewildered, particularly if the dreams always play out the same way.

  • 0033 Angel Number - The Art Of Realism

    0033 Angel Number - The Art Of Realism

    In this article, you will get the opportunity to discover more about the significance of the 0033 angel number.