OA Dermatology http://www.oapublishinglondon.com/oa-dermatology OA Dermatology Clinical significance of p155 antibody in dermatomyositis. http://www.oapublishinglondon.com/article/614 Introduction: Dermatomyositis is associated with an increased risk of malignancy, however, universal screening guidelines are not established. Recently the p155 antibody has been reported, along with an association with malignancy in dermatomyositis. Methods:  We performed a Pubmed search, analysing all papers and those referenced within them forp155 antibody and dermatomyositis. Results: A comprehensive review of the literature shows that p155 antibody is found at an increased incidence in dermatomyositis patients with underlying malignancy of any type, as well as in juvenile dermatomyositis and in those with more severe cutaneous involvement. Conclusion: We conclude that p155 antibody may help clinicians diagnose juvenile dermatomyositis and identify those at risk for more severe disease. Although promising, further investigation is required to determine its role in cancer screening. 07/12/2020 01:12:48 pm The epidermal barrier function and antimicrobial peptides in atopic dermatitis: The role of topical modulation. http://www.oapublishinglondon.com/article/615 The Epidermal barrier is a crucial component of the defensive function of the skin. The main skin protective functions are related to water loss modulation/prevention, UV-protection, anti-oxidant and anti-microbial actions. It is well established that epidermal barrier function is abnormal in subjects suffering from atopic dermatitis (AD). Several evidences have shown that this alteration could be considered as the initial pathogenic factor starting the pathological process of AD. 07/12/2020 01:12:48 pm The best method for steroid use. http://www.oapublishinglondon.com/article/689 No abstract available. 07/12/2020 01:12:48 pm Acne, anti-acne therapies and epidermal barrier functions: the role of adjuvant treatments. http://www.oapublishinglondon.com/article/1014 Acne is the most common skin disease affecting up to 80% of both male and female adolescent. There are several different medications for the treatment of acne, both topical and systemic. Despite the fact that several drugs could be used for acne treatment, acne lesions complete cure is often very difficult to achieve. One important problem which could be considered as a major or relevant cause for this limited therapeutic success is a low patient’s adherence to specific acne treatments and/or recommendations from the dermatologist.Acne treatment and in particular oral retinoids can alter skin barrier function in treated patients. Several therapies used to treat acne can induce in the epidermis changes altering the normal physiological skin barrier function. These alterations are responsible mechanisms causing the skin side effects manifestation in acne treated patients. Even if these alterations could be transient they could be a frequent reason for interrupting or stopping the treatment by the patient. An effective strategy for acne treatment should be based on a simple and effective therapy scheme taking in account that a holistic approach with adjuvant products with the aim to preserve skin barrier function and reducing skin side effects of specific treatments, could help in improving patient adherence to treatments with a consequent better clinical outcome in term of acne lesions resolution.Barrier Repair Therapy (the use of specific emollient/moisturizing products) could represent therefore a relevant strategy as an holistic approach of acne patients, preventing skin barrier alteration, reducing the frequency and intensity of anti-acne specific treatments cutaneous side effects, improving patient adherence to drug treatment with as consequence a better clinical outcome in term of acne lesion improvement. 07/12/2020 01:12:48 pm Association of variation in the CLDN1 gene with atopic dermatitis in a German case-control cohort. http://www.oapublishinglondon.com/article/1015 Atopic dermatitis (AD) is a chronic inflammatory skin disorder caused by complex interaction of genetic and environmental factors. Mutations in the gene encoding filaggrin (FLG), a major structural protein in the epidermis, constitute the most significant known risk factor for AD development so far, implying an impaired skin barrier function as a major pathogenic mechanism in AD development. However, a reduced skin barrier function has been demonstrated in AD patients irrespective of FLG genotype, suggesting that other factors may also modulate skin barrier integrity. It was recently shown the expression of Claudin-1, a major tight junction protein in the granular layer, was reduced in the skin of AD patients and that variation in the CLDN1 gene was associated with AD in two small American populations. For replication of these findings, we investigated the role of CLDN1 variation in an independent German case-control cohort. Six single nucleotide polymorphisms (SNPs) in the CLDN1 gene, including rs16865373 that had shown association with AD in the European American cohort, were genotyped in 451 unrelated AD patients and 375 non-atopic controls by means of restriction enzyme digestion. Allele, genotype and haplotype frequencies were subsequently compared between cases and controls. In this analysis, none of the investigated SNPs or haplotypes in the CLDN1 gene showed a significant association with AD. In conclusion, our results do not support a substantial role for CLDN1 variation in ADpathogenesis. Yet, additional studies in independent cohorts are needed to confirm these results. 07/12/2020 01:12:48 pm Evolution in the management of skin malignant lesions using new radiotherapy techniques. http://www.oapublishinglondon.com/article/1093 Radiotherapy plays an important role in the treatment of skin tumours. For skin carcinomas, external irradiation (kilovoltage X-rays or electrons according to clinical characteristics) is more valuable than interstitial brachytherapy, which is recommended for tumours of the lip and of the nasal vestibule. The electrons are usually used for superficial lesions as the skin cancers, as well as the orthovoltage radiotherapy. In mycosis fungoides, total cutaneous electron beam radiation therapy is efficient for patients with limited superficial plaques. In the classical form of Kaposi's sarcoma, radiotherapy can achieve local control whereas it obtains good palliative results in the epidemic form. New radiotherapy techniques as thehelical tomotherapy (HT) showedincreased advantages as the dose escalation to the target tumor volume and best protection of adjacent organs at risk. The aim of this work is to provide an accurate evaluation of the efficiency and tolerance of old and new radiotherapy techniques in the treatment of different skin tumours and to review the already existing ones. 07/12/2020 01:12:48 pm The importance of the evaluation of androgen levels in adult women with acne: Brazilian casuistic report. http://www.oapublishinglondon.com/article/1112 Acne in adult women is a hard-to-manage frequent disease with many relapse cases. It mostly interferes with the quality of life and causes major social and metabolic losses for patients. This is a transversal retrospective study whose aim is to identify the androgen profile in patients who were treated at the Acne-in-Adult-Women Ambulatory Clinic in the Dermatology Department of Faculdade de Medicina do ABC (FMABC) from 2008 to 2012, and who presented altered frequency and profile of the hormones.         In this study, we reviewed 201 medical records of women above 15 years of age, with the onset or worsening of acne cases, treated at the ambulatory clinic. The levels of the hormones DHEA-S, DHEA, DHT, androstenedione and total and free testosterone were measured in all patients. The evaluation of the hormonal profile showed that 60% of the patients had hyperandrogenemia, and the levels of DHEA were the most frequently elevated.         Therefore, in the face of the importance of the hyperandrogenemia in the pathogenesis of acne, the standardization of circulating androgen levels and the early detection of hyperandrogenic states prove to be useful for a more precise evaluation of each patient and for the choice of the best therapeutic conduct. To establish a model for the research of hormonal profile is paramount for relapse control in the event of a surge of acne breakouts in a woman’s adult life. 07/12/2020 01:12:48 pm HTLV-1 infection and disease with special reference to the dermatological manifestations - a critical review. http://www.oapublishinglondon.com/article/1188 Background: The Human T-Cell Lymphotropic Virus Type 1 (HTLV1) was initially isolated from a patient with cutaneous T-cell lymphoma. Since then HTLV1 has been associated with three main disorders viz. adult T-cell leukaemia/lymphoma (ATLL), HTLV1 associated myelopathy (HAM/TSP) and infective dermatitis associated with HTLV1 (IDH). This review examines the dermatological manifestations in details. Dermatological Manifestations: The skin manifestations range from xerosis to IDH and lymphoma. The prototype of skin involvement is IDH which occurs in childhood. It is characterised by a weeping, erythematous and scaly lesions affecting the face, scalp, retroauricular and flexural areas of the body. Infection with S aureus and β – haemolytic streptococcus maintains these lesions which only improve after prolonged antibiotic therapy. IDH often remits at puberty but may be a forerunner of HAM/TSP or ATLL. The main differential diagnosis is atopic eczema, an important consideration, as treatment and prognosis are different. A peculiar unexplained feature of IDH is that it occurs in certain ethnic groups. It is common in the Caribbean and Sub-Sahara Africa but almost unheard of in Japanese infected individuals. Conclusion: Skin involvement occurs in up to 70% of HTLV1 infected patients, including otherwise asymptomatic HTLV-I carriers. Due to its varied dermatological manifestations HTLV1 is an important consideration in the differential diagnosis in a number of skin disorders occurring in patients living in HTLV1 endemic areas. 07/12/2020 01:12:48 pm Treatment of cellulitis in hospital in the home: a systematic review. http://www.oapublishinglondon.com/article/1189 Aim: Hospital in the Home (HITH) is increasing in popularity due to concerns around cost, safety and limited inpatient hospital beds. This disease-specific systematic review aims to evaluate the efficacy of HITH for the treatment of cellulitis. Method: Thirty-nine relevant articles, including nine randomised controlled trials, were included in this review. Results/Conclusion:Once-daily intravenous dosing regimens (e.g. with cefazolin-probenecid) have been shown to be safe, well tolerated and efficacious for cellulitis. Compared to inpatient care, the mean duration of treatment in HITH is similar, but is delivered at almost half the cost. Patient and carer satisfaction with home-based care is high. Additionally, HITH may be preferable in older patients, due to lower incidence of geriatric complications such as delirium. 07/12/2020 01:12:48 pm The use of poly-L-lactic acid filler in facial volume restoration: A review. http://www.oapublishinglondon.com/article/1304 The article has been forwarded to the production team. The processing may take few weeks. Then the proof will be forwarded to the corresponding author. The final PDF and HTML files will be uploaded when the corrections to the proof are returned by the corresponding author. 07/12/2020 01:12:48 pm Complications following permanent fillers use: A review of causative agents, pathology and treatment options. http://www.oapublishinglondon.com/article/1305 The article has been forwarded to the production team. The processing may take few weeks. Then the proof will be forwarded to the corresponding author. The final PDF and HTML files will be uploaded when the corrections to the proof are returned by the corresponding author. 07/12/2020 01:12:48 pm Diverse effects of cAMP signaling in melanoma support the role of distinct cAMP microdomains in melanomagenesis, metastasis, and resistance to therapy. http://www.oapublishinglondon.com/article/1306 The article has been forwarded to the production team. The processing may take few weeks. Then the proof will be forwarded to the corresponding author. The final PDF and HTML files will be uploaded when the corrections to the proof are returned by the corresponding author. 07/12/2020 01:12:48 pm Novel and promising sun safety interventions: UV photography and shade structures. http://www.oapublishinglondon.com/article/1307 The article has been forwarded to the production team. The processing may take few weeks. Then the proof will be forwarded to the corresponding author. The final PDF and HTML files will be uploaded when the corrections to the proof are returned by the corresponding author. 07/12/2020 01:12:48 pm Systemic contact dermatitis to nickel. http://www.oapublishinglondon.com/article/1466 Nickel is one of the most common contact allergens in the modern world. Nickel allergy prevalence is constantly growing in many countries and represents a major health and socio-economical issue. In certain cases of nickel hypersensitive patients the allergic subjects could be challenged by the allergen not by direct skin contact but when the allergen is introduced to the organism by transmucosal, oral, intravenous, intramuscular, or inhalational route instead. Such process is known as systemic contact dermatitis. This review is devoted on this issue, its causes, clinical manifestations and treatment. 07/12/2020 01:12:48 pm Vitamin D in dermatology. http://www.oapublishinglondon.com/article/1556 Vitamin D is classically known for its role in calcium homeostasis and bone mineralization. However, recent studies have shown that vitamin D is important in numerous physiological processes, including the modulation of cell proliferation, differentiation, and apoptosis, and in neuromuscular, hormonal, and immune functions. On the other hand, vitamin D may also play a role in multiple chronic diseases such as cancer, autoimmune diseases, and infections. In this review, we focus on vitamin D and skin disease. 07/12/2020 01:12:48 pm Infantile haemangioma. http://www.oapublishinglondon.com/article/1557 This review focuses on Infantile Haemangioma, a benign proliferative disorder of infancy. Clinical approach, differential diagnosis, pathogenetic mechanism and new treatment options will be discuss bringing into focus the more recent data on this vascular tumour. 07/12/2020 01:12:48 pm