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Study Finds Cannabinoids Prevent SARS-CoV-2 Variants Cellular Entry

According to a new study released by experts linked with Oregon State University, compounds in cannabis may prevent infection from the virus that causes Covid-19 by inhibiting its entrance into cells. The Journal of Natural Products released an article titled "Cannabinoids Block Cellular Entry of SARS-CoV-2 and Emerging Variants" on Monday.

Author:Suleman Shah
Reviewer:Han Ju
Apr 01, 202210 Shares841 Views
Cannabinoids Prevent COVID- The term cannabinoid refers to any chemical molecule, regardless of structure or origin, that binds to cannabinoid receptors in the body and brain and has effects comparable to those of the Cannabis Sativa plant. The phytocannabinoid (THC) (Delta9-THC or Delta8-THC), the principal psychoactive ingredient in cannabis, is the most well-known cannabinoid. Cannabidiol (CBD) is another critical component of the plant. Cannabinoids' number is in the hundreds. Each has a unique influence on the body.
According to a new study released by experts linked with Oregon State University, compounds in cannabis may prevent infection from the virus that causes Covid-19 by inhibiting its entrance into cells. Journal of Natural Products released an article titled "Cannabinoids Block Cellular Entry of SARS-CoV-2 and Emerging Variants" on Monday.

Role In Treating COVID-19

Small-molecule therapeutic medicines are needed to treat or prevent infections caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which produce COVID-19. These drugs should be used in addition to immunizations. According to research published in the Journal of Nature Products, "orally accessible and with a long historyof safe human usage, these cannabinoids, individually or in hemp extracts, have the potential to prevent and cure the infection by SARS-CoV-2."
The study was led by Richard van Breemen, a scientist from Oregon State University's Global Hemp Innovation Center, College of Pharmacy, and Linus Pauling Institute. In a lab environment, the research reveals that two chemicals present in hemp, cannabigerol acid (CBGA) and cannabidiol acid (CBDA), inhibit coronavirus from accessing cells that generally line internal organs and skin. In the research, these acids were able to bind to the SARS-CoV-2 spike protein, which acids acids acids were able to attach to the SARS-CoV-2 spike protein in the study, which is the same target employed in COVID-19 vaccines and antibody treatment. Once bound, this step may prevent a vital phase in the pathogen's process of infecting the cell.
Van Breemen went on to say that CBDA and CBGAwere equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, which was first identified in South Africa, and that "our research revealed the hemp compounds were equally efficient against variants of SARS-CoV-2, which include variant B.1.351, which was being detected in South Africa."

Spike Proteins

The spike protein is the same portion of the virus that Covid-19 vaccinations and antibody treatments target. SARS-CoV-2 includes three additional structural proteins, 16 nonstructural proteins, and many compounds van Breemen refers to as "accessory" proteins, all possible targets for medications designed to prevent Covid-19. "Any element of the infection and replication cycle is a potential target for antiviral intervention," van Breeman said. "The attachment of the spike protein's receptor-binding domain to the human cell surface receptor ACE2 is a vital stage in that cycle." "This suggests that cell entrance inhibitors, such as hemp acids, might be employed to prevent SARS-CoV-2 infection and shorten illnesses by stopping virus particles from entering human cells." They attach to the spike proteins, preventing them from interacting with the ACE2 enzyme, prevalent on endothelial cells' outer membrane in the lungs and other organs."
Even though further research is required, van Breemen said that the cannabinoids might be converted into medications to prevent or cure Covid-19. "These chemicals are safe to consume orally and have a long history of usage in humans," van Breemen said. "They have the potential to both prevent and cure SARS-CoV-2 infection." The hemp plant produces CBDA and CBGA as precursors to CBD and CBG, which are well-known to many customers. However, they vary from acids from acids how and are not found in hemp products." Van Breeman also said that the study revealed cannabis was effective against new forms of the virus, which he described as "one of the key worries" for healthauthorities and physicians during the epidemic. "These mutations are well recognized for evading antibodies against early lineage SARS-CoV-2, which is troubling. Current immunization regimens depend on the initial lineage spike protein as an antigen," Van Breemen stated.

Conclusion

"Our findings demonstrate that CBDA and CBGA are effective against the two variations we studied, and we expect that trend to continue with other current and future variants." Van Breemen stated. "Resistance variations might still emerge despite the widespread usage of marijuana," the researcher continued, "but the combination of vaccination and CBDA/CBGA therapyshould create a considerably more difficult environment for SARS-CoV-2."
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Suleman Shah

Suleman Shah

Author
Suleman Shah is a researcher and freelance writer. As a researcher, he has worked with MNS University of Agriculture, Multan (Pakistan) and Texas A & M University (USA). He regularly writes science articles and blogs for science news website immersse.com and open access publishers OA Publishing London and Scientific Times. He loves to keep himself updated on scientific developments and convert these developments into everyday language to update the readers about the developments in the scientific era. His primary research focus is Plant sciences, and he contributed to this field by publishing his research in scientific journals and presenting his work at many Conferences. Shah graduated from the University of Agriculture Faisalabad (Pakistan) and started his professional carrier with Jaffer Agro Services and later with the Agriculture Department of the Government of Pakistan. His research interest compelled and attracted him to proceed with his carrier in Plant sciences research. So, he started his Ph.D. in Soil Science at MNS University of Agriculture Multan (Pakistan). Later, he started working as a visiting scholar with Texas A&M University (USA). Shah’s experience with big Open Excess publishers like Springers, Frontiers, MDPI, etc., testified to his belief in Open Access as a barrier-removing mechanism between researchers and the readers of their research. Shah believes that Open Access is revolutionizing the publication process and benefitting research in all fields.
Han Ju

Han Ju

Reviewer
Hello! I'm Han Ju, the heart behind World Wide Journals. My life is a unique tapestry woven from the threads of news, spirituality, and science, enriched by melodies from my guitar. Raised amidst tales of the ancient and the arcane, I developed a keen eye for the stories that truly matter. Through my work, I seek to bridge the seen with the unseen, marrying the rigor of science with the depth of spirituality. Each article at World Wide Journals is a piece of this ongoing quest, blending analysis with personal reflection. Whether exploring quantum frontiers or strumming chords under the stars, my aim is to inspire and provoke thought, inviting you into a world where every discovery is a note in the grand symphony of existence. Welcome aboard this journey of insight and exploration, where curiosity leads and music guides.
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