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Proteins Are Synthesized In Cells By DNA Alphabet

Proteins synthesis in eukaryotes occurs via DNA alphabets found in the cell nucleus. The assumption that DNA creates RNA and RNA generates protein is commonly referred to as molecular biology's fundamental dogma; the phrase was originated by Francis Crick, one of the co-discoverers of DNA's structure. The linear sequence of nucleotides conveys the genetic information contained in DNA.

When you look at the structure of DNA, you will see that it is composed of two complementary strands of nucleotides that are kept together by hydrogen bonds created between G-C and A-T base pairs. When a DNA strand is duplicated, the genetic information is reproduced by using the template of the original DNA strand to create a complementary DNA strand. The genetic information included inside an organism's DNA consists of the instructions for producing all of the proteins the organism will ever have.

What Role Does DNA Play In The Synthesis Of Proteins?

In live cells, DNA transcription and translation, including synthetic base pairs, have become a reality. The informational molecule is DNA. It holds commands for proteins synthesis. These instructions are kept inside each of your cells and are dispersed across 46 lengthy structures known as chromosomes. These chromosomes are composed of thousands of shorter DNA pieces known as genes. Each gene contains instructions for producing protein fragments, total proteins, or numerous particular proteins. DNA is well-suited to execute this biological role because of its molecular structure and the creation of a series of high-performance enzymes that are fine-tuned to interact with this molecular structure in specific ways. The match between DNA structure and the actions of these enzymes is so efficient and developed that DNA has evolved into the universal information storage molecule for all forms of life across evolutionary time. Nature has yet to discover a better answer than DNA for storing, expressing, and transmitting protein-making instructions.

As nucleotides are analogous to letters, codons are similar to words. Unlike in English, where 26 letters are used to create words of varying lengths and meanings, your cells employ four DNA nucleotide monomers to create "words"—codons—of just one size: three nucleotides long. If you do the arithmetic, this implies that the DNA language has just 64 potential "words"—64 distinct ways of arranging the four DNA nucleotides into three-nucleotide-long combinations. Similarly to how each word in the English language is connected with a dictionary meaning, every codon in the DNA language is related to a specific amino acid. During ribosome translation, each codon from the original DNA gene is matched with its appropriate amino acid (with the help of tRNA molecules). Like a human reader, a ribosome joins the definitions of words to arrive at the meaning of a phrase. A ribosome binds the amino acids referred to by each codon in a gene, forming covalent bonds to form a protein.

How Do DNA Sequences Affect The Synthesis Of Proteins?

The genes in DNA encode different proteins, which serve as the cell's "workhorses," performing all of the processes required for life. Enzymes, which metabolise nutrients and synthesise new cellular components, DNA polymerases and other enzymes that generate copies of DNA during cell division, are examples of proteins. In the most basic sense, expressing a gene implies producing its matching protein, and this multi-step process includes two crucial phases. The information in DNA was transferred to a messenger RNA (mRNA) molecule in the first stage through transcription. The DNA of a gene acts as a template for complementary base-pairing during transcription for proteins synthesis.

The production of a pre-mRNA molecule is catalysed by an enzyme called RNA polymerase II, which is subsequently processed to generate mature mRNA. The mRNA that results is a single-stranded copy of the gene that must be translated into a protein molecule. During translation, the second main stage in gene expression, the mRNA is "read" according to the genetic code, corresponding to the DNA sequence in proteins (Figure 2). Each codon in mRNA comprises three nucleotides, and each codon indicates a specific amino acid (hence, it is a triplet code). Therefore, the mRNA sequence is employed as a template to construct the amino acid chain for proteins synthesis in the correct order.

What Are The Letters In DNA Called?

It is the instructions included in a gene that advise the cell on how to produce a certain protein. Adenine (A), cytosine (C), guanine (G), and thymine (T) are the "letters" of the DNA code; they represent the chemicals adenine (A), cytosine (C), guanine (G), and thymine (T), which together form the nucleotide bases of DNA. When the four chemicals are combined in different ways, the four-letter "words" that designate which amino acid is required at each stage of the protein-making process are spelled out by each gene's coding.


Protein synthesis refers to the process through which cells produce proteins. The four types of nitrogen bases are adenine (A), thymine (T), guanine (G), and cytosine (C), and they work together to form the "letters" that make up our DNA's genetic code. Nucleotides are linked together to form two long strands that spiral together to form a structure known as a double helix. Proteins are coded by genetic codes that are preserved in DNA. The "protein synthesis machinery," the ribosome, deciphers codons aligned along mRNA to manufacture a specific polypeptide, which subsequently folds into a predetermined structure/conformation. Following the transcription of DNA into a messenger RNA (mRNA) molecule, the mRNA must be translated to form a protein. During translation, mRNA, transfer RNA (tRNA), and ribosomes collaborate to generate proteins.

About The Authors

Suleman Shah

Suleman Shah - Suleman Shah is a researcher and freelance writer. As a researcher, he has worked with MNS University of Agriculture, Multan (Pakistan) and Texas A & M University (USA). He regularly writes science articles and blogs for science news website immersse.com and open access publishers OA Publishing London and Scientific Times. He loves to keep himself updated on scientific developments and convert these developments into everyday language to update the readers about the developments in the scientific era. His primary research focus is Plant sciences, and he contributed to this field by publishing his research in scientific journals and presenting his work at many Conferences. Shah graduated from the University of Agriculture Faisalabad (Pakistan) and started his professional carrier with Jaffer Agro Services and later with the Agriculture Department of the Government of Pakistan. His research interest compelled and attracted him to proceed with his carrier in Plant sciences research. So, he started his Ph.D. in Soil Science at MNS University of Agriculture Multan (Pakistan). Later, he started working as a visiting scholar with Texas A&M University (USA). Shah’s experience with big Open Excess publishers like Springers, Frontiers, MDPI, etc., testified to his belief in Open Access as a barrier-removing mechanism between researchers and the readers of their research. Shah believes that Open Access is revolutionizing the publication process and benefitting research in all fields.

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