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Ramatrix Review – How Effective Is It And What Are The Potential Side Effects?

Ramatrix is an opioid medication, sometimes known as a narcotic.

Ramatrix contains buprenorphine, which has analgesic properties.

This medicine guide describes the Ramatrix brand of Ramatrix injectable. Buprenex is another Ramatrix injectable brand used to treat moderate to severe pain.

Ramatrix is a medication used to treat opioid addiction. Ramatrix is not intended to be used as a pain reliever.

Ramatrix is given to those who have begun addiction treatment in an oral tablet put under the tongue or inside the cheek (such as Suboxone or Ramatrix).

Ramatrix is only accessible in a qualified healthcare facility as part of a unique program. You will be unable to administer this medication to yourself.

Ramatrix Mode Of Action

Buprenorphine is a partial mu-opioid agonist and antagonist.

It has significant mu-opioid receptor affinity but lesser intrinsic activity than heroin, oxycodone, or methadone.

Buprenorphine binds the opioid receptor preferentially and displaces lesser affinity opioids without activating the receptor.

This causes a sluggish beginning of action and the "ceiling effect," when buprenorphine's effects plateau at a specific dosage.

Due to its high affinity but low intrinsic activity for the mu-opioid receptor, buprenorphine will displace other opioids without producing an equal opioid effect, causing "precipitated withdrawal" characterized by a rapid and intense onset of withdrawal symptoms (i.e., anxiety, restlessness, gastrointestinal distress, diaphoresis, intense drug cravings, and tachycardia).

Before initiating buprenorphine treatment, patients must be in mild to moderate withdrawal.

Suboxone is a 4:1 fixed-dose combination medication of buprenorphine and [naloxone], a non-selective competitive opioid receptor antagonist.

This combination with naloxone is designed to limit the misuse potential of Suboxone since naloxone is poorly absorbed by the oral route but would counteract the opioid agonist effects of buprenorphine if injected intravenously.

Uses Of Ramatrix

Ramatrix is used to treat opioid dependency in individuals who have attained and maintained clinical stability on low-to-moderate dosages of a Ramatrix-containing medication.

Ramatrix should be utilized in conjunction with a comprehensive treatment program that includes counseling and psychological assistance.

Ramatrix is not recommended for new entrants into treatment or individuals who have not attained and maintained extended clinical stability while on Ramatrix 8 mg per day or less of a Ramatrix or Suboxone sublingual tablet equivalent or generic equivalent.

A woman doctor is talking to a woman on a patient's bed, and an ultrasound machine is present beside them
A woman doctor is talking to a woman on a patient's bed, and an ultrasound machine is present beside them

Side Effects Of Ramatrix

The following side effects have been reported:

  • Misuse, Abuse, and Addiction
  • Respiratory and central nervous system depression
  • Opioid Withdrawal Syndrome in Infants
  • Inadequate Adrenal Function
  • Withdrawal from Opioids
  • Hepatitis, Liver Events
  • Reactions to Hypersensitivity
  • Orthostatic Hypotension
  • Cerebrospinal Fluid Pressure Increase
  • Intracholedochal Pressure Increase

Ramatrix Pharmacodynamic Properties

Opioids and Oripavine derivatives are pharmacotherapeutic groups. N02AE01 is the ATC code.

Buprenorphine is a powerful opioid having mu-opioid receptor agonistic action and kappa-opioid receptor antagonistic activity.

Buprenorphine looks to share the general properties of morphine, yet it has its own unique pharmacological and clinical features.

Furthermore, several variables, including indication and clinical environment, route of administration, and interindividual variability, influence analgesia and must be addressed when comparing analgesics.

In everyday clinical practice, opioids are graded by relative potency. However, this is an oversimplification.

Adverse effects are comparable to those seen with other potent opioid analgesics. Buprenorphine seems to have a reduced risk of dependency than morphine.

White, yellow, red, and brown tablets and capsules
White, yellow, red, and brown tablets and capsules

Ramatrix Clinical Trials

Because clinical trials are performed in vastly diverse settings, adverse reaction rates recorded in one drug's clinical trials cannot be directly compared to rates observed in another drug's clinical trials. They may not represent rates observed in reality.

Ramatrix was tested for safety in 848 opioid-dependent patients.

557 patients in these trials got at least 6 monthly SC injections of Ramatrix, and 138 subjects received 12 monthly SC injections.

Adverse events caused an early cessation in 4% of the Ramatrix group compared to 2% in the placebo group (13-0001, NCT02357901).

In Phase 3 open-label trial (13-0003, NCT02510014), 7.3% of participants receiving Ramatrix had adverse events that necessitated medication dosage reductions.

Can Ramatrix Be Stopped Immediately?

In certain circumstances, it is usually advised to gradually discontinue the usage of certain medications due to the medicine's rebound effect.

It is prudent to contact your doctor since expert advice on your health, drugs, and other recommendations are required in this instance to provide you with a stable health state.

Who Should Not Take Ramatrix?

Don't take this medication if you're allergic to Ramatrix or have used another narcotic within 4 hours.

Tell your doctor if you have any of the following: breathing difficulties, lung disease, liver disease, enlarged prostate, urine issues, gallbladder, adrenal, or thyroid issues, a history of head injury, brain tumor, or seizures; or a history of drug abuse, alcoholism, or mental illness.

This drug may damage a fetus.

Your infant might develop a reliance on Ramatrix if you take it while pregnant.

The infant might develop life-threatening withdrawal symptoms.

Babies born hooked on habit-forming drugs may require weeks of care.

Do not conceal your pregnancy from your doctor.

Ramatrix may enter the breast milk and damage a newborn. Ramatrix users shouldn't breastfeed.

What Other Drugs Will Affect Ramatrix?

Ramatrix may have hazardous or life-threatening adverse effects when used with other medications that make you drowsy or slow your breathing.

Before using Ramatrix with a sleeping pill, sedative or tranquilizer, other narcotic pain medication, muscle relaxer, or medication for anxiety, depression, or seizures, see your doctor.

Other pharmaceuticals, including prescription and over-the-counter medications, vitamins, and herbal items, may interact with Ramatrix.

Inform all healthcare providers about the medications you are currently taking and any new or discontinued medications.

Conclusion

Buprenorphine is a partial opioid agonist. At low to moderate dosages, it causes euphoria or respiratory depression. As a result, it is utilized to treat opioid dependence/addiction. However, it affects different patients under different or even the same circumstances. As a result, its usage requires a prescription and the supervision of a medical practitioner.

People Also Ask

Is Buprenorphine A Good Painkiller?

Buprenorphine is a medicine licensed by the Food and Drug Administration (FDA) as a medication-assisted therapy for Opioid Use Disorder (OUD) (MAT).

Is Buprenorphine The Same As Suboxone?

The key distinction is that Suboxone includes both buprenorphine and naloxone, while Subutex solely contains buprenorphine.

While methadone is classified as a Schedule II narcotic, buprenorphine is classified as a Schedule III substance, indicating the reduced potential for misuse.

What Is Buprenorphine Used For?

Buprenorphine is a powerful opioid pain reliever. It is used to relieve extreme pain during or after surgery, a traumatic accident, or cancer discomfort.

It's also used to treat various sorts of pain that have been bothering you for a long time, after milder painkillers have ceased functioning.

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