OA Epidemiology

Did the Dutch pneumococcal vaccination campaign decrease the need for antibiotics in children?

Proceedings of the 2013 annual meeting of the Netherlands Epidemiology Society

Volume 1 Issue S1 Abstract 60


Giedre Gefenaite, University Medical Center of Groningen, the Netherlands
Maarten J. Bijlsma, University of Groningen, Groningen, the Netherlands
Jens Bos, University of Groningen, Groningen, the Netherlands
Eelko Hak, University Medical Center of Groningen, the Netherlands

Streptococcus pneumoniae  causes childhood  respiratory mucosal infections that are frequently treated with antibiotics. In June 2006 an infant pneumococcal vaccination campaign  (PVC) was introduced in the Netherlands; 94% of children born after April 2006 were vaccinated. To estimate the effectiveness of PVC on mucosal infections we analysed the trends of antibiotic use for primary care of AOM and pneumonia from 1999 to 2011.

This time trend study was performed in children 1 to 5 years of age. The IADB.nl prescription database was used which contains pharmacy-dispensing data from 55 community pharmacies in the Netherlands. Seasonal autoregressive integrated moving average (SARIMA) models were applied to estimate the impact of PVC (before-after change in % of monthly proportion of the amoxicillin, azithromycin and/or cotrimoxazol prescriptions within a particular age group in a particular year). Children born before April 2006 were considered to be unvaccinated, and children born after this date were considered to be vaccinated.

Preliminary results showed that the use of antibiotics after the introduction of PVC as compared to before was slightly reduced.

There is a tendency towards a decrease in antibiotic use for pneumonia and AOM in young children after the introduction of PVC, however it needs further study.

Published: 06 Jun, 2013

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