Epidiolex For Schizophrenia - Does It Really Work?
Cannabis has more than 100 different cannabinoids, making it a very diverse plant. Several studies back up the conclusion that using cannabis is linked to psychosis and schizophrenia. Epidiolex for schizophrenia is a name-brand antipsychotic medication.
The Food and Drug Administration has given it permission to treat seizures caused by Lennox-Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex (TSC).
Epidiolex has the active ingredient cannabidiol (CBD).
A liquid solution is provided for oral administration.
Epidiolex can be used safely by both adults and children over the age of one.
Although they are uncommon, serious adverse effects from Epidiolex can happen.
If you experience severe adverse effects, believe you are experiencing a medical emergency, or believe your symptoms are life-threatening, call your doctor immediately.
The following are examples of serious side effects, which are explained in more detail below under "Side effect details":
Suicidal thoughts or behavior
Severe allergic reaction
Sedation (sleepiness, loss of coordination, and trouble thinking clearly)
Users frequently experienced drowsiness as a side effect during clinical trials.
Up to 25% of users reported experiencing particularly restless sleep.
A placebo treatment, which contains no actual medication, has a 9% somnolence rate.
During clinical trials, up to 12% of people who took Epidiolex felt tired or had low energy.
Additionally, 4% of those taking a placebo reported feeling tired.
Additionally, throughout clinical investigations, 3% to 6% of Epidiolex users reported feeling drowsy.
1% of those taking a placebo reported feeling sleepy. Sedation signs can include:
Being unable to safely operate equipment or machinery, such as a car
Trouble thinking clearly
Loss of coordination
Sleepiness
People taking greater dosage of Epidiolex generally experience If you are taking Epidiolex, don't drive or use machinery until you know how it will affect you. Those taking lower doses are more likely to experience these side effects than those taking higher doses.
Consult your doctor if you or your kid has any of these side effects after taking Epidiolex.
They might need to adjust your Epidiolex dosage or have you try an alternative drug.
If you are taking Epidiolex, don't drive or use machinery until you know how it will affect you.
Between 8% and 25% of participants in clinical tests who were taking the medication had elevated liver enzyme levels.
High levels of liver enzymes in the blood may indicate a liver issue.
On the other hand, up to 3% of people who took a placebo (a medicine with no active ingredient) had higher levels of liver enzymes.
Among the signs of liver issues are:
Dark-colored urine
Jaundice (yellowing of your skin and the whites of your eyes)
Loss of appetite
Fatigue
Pain in your upper abdomen
Vomiting
Nausea
According to clinical research, Epidiolex users who took greater doses experienced liver issues more frequently than those who took lesser doses of the medication.
During clinical trials, liver damage was one of the most common reasons why people stopped taking Epidiolex.
If you have liver disease, there is an increased risk of liver damage when using Epidiolex.
Before beginning Epidiolex, be sure to discuss your medical historywith your doctor.
Your doctor will examine your liver function before you start taking Epidiolex.
This enables them to check that your liver is in good enough shape for you to take this medication.
Your doctor may continue to perform lab tests to check on your liver function while you are taking Epidiolex.
If liver damage happens while you are being treated, you may need to stop taking the medicine.
If you experience any liver-related symptoms while taking Epidiolex, inform your doctor right away.
Suicidal ideas and actions may be made more likely.
This risk is further raised by additional anti-epileptic drugs used to treat epilepsy.
The FDA examined a number of studies conducted on people taking anti-epileptic medications.
There were 11 different medicines examined.
According to this investigation, epilepsy patients were more likely to have suicidal thoughts and actions.
People who weren't taking anti-epilepsy medications had a risk that was 80% higher than those who were.
After just one week of using the medicine, the danger increased.
Before Epidiolex was made accessible, these studies were conducted.
How frequently Epidiolex users engage in suicidal conduct or ideation is unknown.
Your doctor will keep a careful eye on you or your child while you are taking Epidiolex for any indications of new or worsening sadness or strange mood swings.
If you observe these symptoms in yourself or your kid, or if you have thoughts of harming yourself, speak with your doctor immediately.
The treatment of seizures linked to the rare and severe forms of epilepsy, Lennox-Gastaut syndrome and Dravet syndrome, in patients two years of age or older, has been approved by the U.S. Food and Drug Administration.
Critics are outraged by the $32,500 list price of Epidiolex, the first cannabis medication to hit the market.
It's official - the first CBD product with FDA approval is now available.
This morning, GW Pharmaceuticals announced that Epidiolex, a cannabinoid that has been approved to treat two very rare types of epilepsy, can now only be bought with a prescription.
Other CBD, "hemp," and medical marijuana products may include trace quantities of THC, but Epidiolex, a pharmaceutical-grade cannabidiol oil product made by Greenwich, does not.
Some of the most common side effects of Epidiolex are drowsiness, decreased appetite, diarrhea, fever, vomiting, feeling very tired and weak, rash, trouble sleeping, infections, and infections.
Suleman Shah is a researcher and freelance writer. As a researcher, he has worked with MNS University of Agriculture, Multan (Pakistan) and Texas A & M University (USA). He regularly writes science articles and blogs for science news website immersse.com and open access publishers OA Publishing London and Scientific Times. He loves to keep himself updated on scientific developments and convert these developments into everyday language to update the readers about the developments in the scientific era. His primary research focus is Plant sciences, and he contributed to this field by publishing his research in scientific journals and presenting his work at many Conferences.
Shah graduated from the University of Agriculture Faisalabad (Pakistan) and started his professional carrier with Jaffer Agro Services and later with the Agriculture Department of the Government of Pakistan. His research interest compelled and attracted him to proceed with his carrier in Plant sciences research. So, he started his Ph.D. in Soil Science at MNS University of Agriculture Multan (Pakistan). Later, he started working as a visiting scholar with Texas A&M University (USA).
Shah’s experience with big Open Excess publishers like Springers, Frontiers, MDPI, etc., testified to his belief in Open Access as a barrier-removing mechanism between researchers and the readers of their research. Shah believes that Open Access is revolutionizing the publication process and benefitting research in all fields.
Han Ju
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